The teenager and skateboarder Alex is interviewed by Detective Richard Lu that is investigating the death of a security guard in the rail yards severed by a train who was apparently hit by a skate board. While dealing with the separation process of his parents and the sexual heat of his virgin girlfriend Jennifer, Alex writes his last experiences in Paranoid Park with his new acquaintances and how the guard was killed, trying to relieve his feeling of guilty from his conscience.

The residents of a rural mining town discover that an unfortunate chemical spill has caused hundreds of little spiders to mutate overnight to the size of SUVs. It’s then up to mining engineer Chris McCormack and Sheriff Sam Parker to mobilize an eclectic group of townspeople, including the Sheriff’s young son, Mike, her daughter, Ashley, and paranoid radio announcer Harlan, into battle against the bloodthirsty eight-legged beasts.